Introduction




Hi, I'm Yuval Ebenstein and Since August 2011 I have been putting together the NanoBioPhotonics research group in Tel-Aviv university. This blog is our presence on the web until we have a proper website. Unfortunately, I'm really bad at maintaining these things... but anyways:
We explore some exciting biological systems utilizing tools and reagents from the realm of nano-technology. We try learning new things about these systems by zooming in on individuals - single cells, single chromosomes and single molecules.
Research in the lab is highly multi and inter disciplinary and our team is composed of chemists, biologists and physicists who are interested in learning from each other and doing some great (but sometimes risky...) stuff at the very forefront of science.
If you would like to know more about our research or would like to join the group, please contact me at:
uv(AT)post.tau.ac.il

Tuesday, May 13, 2014

Lighting up individual DNA damage sites by in-vitro repair synthesis


Our work on direct visualization of DNA damage was just accepted to JACS

We repair extracted genomic DNA in a tube containing a cocktail of repair enzymmes and fluorescent nucleotides. Damaged DNA lights up as it is repaired and is visualized as fluorescent spots along the DNA molecules.

Monday, December 30, 2013

Toward Single-Molecule Optical Mapping of the Epigenome

Our new review is out in ACS NANO.
We show exciting preliminary results of engineered 5hmC patterns on Lambda DNA. Individual molecules are stretched and imaged in silicon nano-channel arrays
Check it out here:
http://pubs.acs.org/doi/abs/10.1021/nn4050694

Friday, November 29, 2013

I've been told that it's important to show off our winning of an ERC starters grant...


We got 1.63 million Euros for our project: Beads on String Genomics: Experimental Toolbox for Unmasking Genetic / Epigenetic Variation in Genomic DNA and Chromatin.

Monday, July 15, 2013

Optical detection of epigenetic marks: sensitive quantification and direct imaging of individual hydroxymethylcytosine bases

The first 100% independent work from our lab and the first of its kind observation of individual epigenetic modifications in genomic DNA. Just published in Chemical Communications. Check it out