Introduction

Hi, I'm Yuval Ebenstein and Since August 2011 I have been leading the NanoBioPhotonics research group in Tel-Aviv university. We explore some exciting biological systems utilizing tools and reagents from the realm of nano-technology. We try learning new things about these systems by zooming in on individuals - single cells, single chromosomes and single molecules.
Research in the lab is highly multi and inter disciplinary and our team is composed of chemists, biologists and physicists who are interested in learning from each other and doing some great (but sometimes risky...) stuff at the very forefront of science. I'll try updating news here as well but....

*************We now have a real website*************

Check it out:

WWW.NANOBIOPHOTONIX.COM

Tuesday, August 5, 2014

High throughput quantification of 5hmC - Published in Ananlytical Chemistry

We further developed our method for optical detection of 5hmC to be compatible with measurements on a multiwell plate. Now ~350 samples can be measured simultaneously. We demonstrate a measurement of 190 mouse tissue samples

Check it out here: Spectroscopic Quantification of 5-Hydroxymethylcytosine in
Genomic DNA

Tuesday, May 13, 2014

Lighting up individual DNA damage sites by in-vitro repair synthesis

Our work on direct visualization of DNA damage was just accepted to JACS

We repair extracted genomic DNA in a tube containing a cocktail of repair enzymmes and fluorescent nucleotides. Damaged DNA lights up as it is repaired and is visualized as fluorescent spots along the DNA molecules.

Monday, December 30, 2013

Toward Single-Molecule Optical Mapping of the Epigenome

Our new review is out in ACS NANO.
We show exciting preliminary results of engineered 5hmC patterns on Lambda DNA. Individual molecules are stretched and imaged in silicon nano-channel arrays

Check it out here:
http://pubs.acs.org/doi/abs/10.1021/nn4050694

Friday, November 29, 2013

I've been told that it's important to show off our winning of an ERC starters grant...

We got 1.63 million Euros for our project: Beads on String Genomics: Experimental Toolbox for Unmasking Genetic / Epigenetic Variation in Genomic DNA and Chromatin.