We show exciting preliminary results of engineered 5hmC patterns on Lambda DNA. Individual molecules are stretched and imaged in silicon nano-channel arrays
http://pubs.acs.org/doi/abs/10.1021/nn4050694
Introduction
Hi, I'm Yuval Ebenstein and Since August 2011 I have been leading the NanoBioPhotonics research group in Tel-Aviv university. We explore some exciting biological systems utilizing tools and reagents from the realm of nano-technology. We try learning new things about these systems by zooming in on individuals - single cells, single chromosomes and single molecules.
Research in the lab is highly multi and inter disciplinary and our team is composed of chemists, biologists and physicists who are interested in learning from each other and doing some great (but sometimes risky...) stuff at the very forefront of science. I'll try updating news here as well but....
*************We now have a real website*************
Check it out:
Monday, December 30, 2013
Toward Single-Molecule Optical Mapping of the Epigenome
Our new review is out in ACS NANO.
We show exciting preliminary results of engineered 5hmC patterns on Lambda DNA. Individual molecules are stretched and imaged in silicon nano-channel arrays
Check it out here:
http://pubs.acs.org/doi/abs/10.1021/nn4050694
We show exciting preliminary results of engineered 5hmC patterns on Lambda DNA. Individual molecules are stretched and imaged in silicon nano-channel arrays
http://pubs.acs.org/doi/abs/10.1021/nn4050694
Friday, November 29, 2013
I've been told that it's important to show off our winning of an ERC starters grant...
We got 1.63 million Euros for our project: Beads on String Genomics: Experimental Toolbox for Unmasking Genetic / Epigenetic Variation in Genomic DNA and Chromatin.
Sunday, September 1, 2013
Wednesday, July 24, 2013
Saturday, July 20, 2013
Monday, July 15, 2013
Optical detection of epigenetic marks: sensitive quantification and direct imaging of individual hydroxymethylcytosine bases
The first 100% independent work from our lab and the first of its kind observation of individual epigenetic modifications in genomic DNA. Just published in Chemical Communications. Check it out
Beyond sequencing: optical mapping of DNA in the age of nanotechnology and nanoscopy
We were very happy to be invited to write this short review for a special issue on bio-nano-technology in Current opinion in biotechnology. It really gave us the opportunity to see what was going on in the field and to refine our opinion on where this technology is going. Read the review here
Saturday, July 13, 2013
Stretching DNA molecules in nanochannels allows structural and copy-number variations to be visualized like beads on a string.
We wrote a News & Views for Nature Biotechnology about the the very cool paper
Genome mapping on nanochannel arrays for structural variation analysis and sequence assembly by the teams of Ming Xiao and Pui-Yan Kwok.
Genome mapping on nanochannel arrays for structural variation analysis and sequence assembly by the teams of Ming Xiao and Pui-Yan Kwok.
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